Is Ubiquinol Safe? FAQs & Supplement Safety Review

woman in kitchen with laptop looking at vitamin bottle
Written by Sid Shastri M.Sc.
clock-line icon
3 minutes

As with all supplements, it’s natural to be concerned with how safe Ubiquinol is for your overall health. You can be assured that Kaneka Ubiquinol® has been rigorously tested to ensure its safety and effectiveness. When taken as directed in product labeling, or as recommended by your healthcare provider, Ubiquinol is safe and helps support optimal heart health, promotes the body’s cellular energy production, and protects cells from free radical damage caused by oxidative stress among other benefits.1 This is why, when you purchase a Ubiquinol supplement, you should always look for the Kaneka Quality Seal on the package.

Related: Buying the Right Ubiquinol Supplement: A Checklist

Keep reading to learn more about Ubiquinol and its safety and health benefits.

Ubiquinol Is Naturally Produced in the Body

Although Ubiquinol is naturally produced in your body, many people can benefit from taking a Ubiquinol supplement. There are two predominant forms of CoQ10 which occur naturally in the body: Ubiquinol (the reduced form of CoQ10) and Ubiquinone (the oxidized form of CoQ10). While both the Ubiquinol and Ubiquinone forms of CoQ10 play important roles in cellular energy production and other processes, our bodies need to convert Ubiquinone into Ubiquinol so it can perform certain vital functions. For example, in order for CoQ10 to confer antioxidant protection, it must be in the Ubiquinol form. However, as we age, it becomes harder for our bodies to convert Ubiquinone into Ubiquinol. That’s where Ubiquinol supplements come in. Taking a Ubiquinol supplement bypasses the need for conversion and helps to replenish Ubiquinol levels more efficiently, which is especially important for those who are over 40 or taking a statin.1,2,3 

Read More: Learn More About the Benefits of Ubiquinol

Are There Side Effects from Taking Ubiquinol?

Kaneka Ubiquinol® has been clinically studied for safety and demonstrated to be safe and well tolerated.2 You may find that it is best to take your Ubiquinol supplement in the morning or at lunch time rather than later in the day, as some people have reported minor sleep difficulties when taking Ubiquinol in the evening or at bedtime.

Related: When to Take Ubiquinol CoQ10: Morning or Night?

Is Ubiquinol Safe to Take While Pregnant?

There are no adequate and well-controlled clinical trials demonstrating that Ubiquinol supplements are safe to take during pregnancy. There is also no existing evidence that Ubiquinol is unsafe during pregnancy. Talk to your doctor before using Ubiquinol if you are pregnant or planning to become pregnant.

How Much Ubiquinol is Recommended per Day?

A typical daily dosage of Ubiquinol is 100mg per day, which is the amount generally recommended on supplement labels.

Can You Take Ubiquinol Daily?

Yes! There are several benefits to taking a Ubiquinol supplement daily. In addition to the aforementioned benefits of taking a Ubiquinol supplement, once daily Ubiquinol can replenish CoQ10 blood levels depleted by statin cholesterol medicines.3 Ubiquinol is also a powerful lipid-soluble antioxidant that helps neutralize free radicals.4 In fact, in a survey of primary care physicians who recommend CoQ10 to patients, Ubiquinol is the preferred form of CoQ10 for cardiovascular benefits and general health. For optimal absorption, take Ubiquinol with a meal.

In conclusion, Ubiquinol has been shown to be safe, and can offer substantial health benefits, particularly when taken regularly. If you are new to taking Ubiquinol, download our Beginner’s Guide for more helpful information.

Written by:

Sid Shastri M.Sc.

Kaneka Nutrients’ Director of Research

Sid Shastri, M.Sc., a recognized expert in Ubiquinol, probiotics, and health sciences, currently holds the position of Director of Research at Kaneka Nutrients.

References

Pallotti F, Bergamini C, Lamperti C, Fato R. The Roles of Coenzyme Q in Disease: Direct and Indirect Involvement in Cellular Functions. Int J Mol Sci. 2021 Dec 23;23(1):128
2 Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28.
3 Zlatohlavek L, Vrablik M, Grauova B, Motykova E, Ceska R. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33 Suppl 2:98-101.
https://pubmed.ncbi.nlm.nih.gov/2352956/
4 Frei B, Kim MC, Ames BN.Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. 
Proc Natl Acad Sci U S A. 1990 Jun;87(12):4879-83
 

As seen in:

  • ABC Logo
  • The Dr. OZ Show Logo
  • Fox Logo
  • Whole Foods Magazine Logo
  • CBS Logo