Mark
*Not an actual patient
Male, age 47
Presentation
- Patient visits your office for his annual exam
- Mark is Director of Sales at a technology company
- Married, with 3 kids
- Overweight; BMI 28.1
- Nonsmoker
- Says he's trying to eat healthier, but he has 1 beer per day after dinner
- Belongs to a gym and a men's basketball league
History
- Diagnosed with hyperlipidemia 7 years ago
- History of asthma
- States his job has been stressful, with long hours
Current Treatment
- Began taking low-dose atorvastatin at diagnosis of high cholesterol; last year Mark needed a dose increase
- Uses an inhaler occasionally for asthma symptoms
- Takes a multivitamin daily and additional vitamin C
Mark asks, "What else can I do for my overall health?"
For the patient taking a statin, consider Ubiquinol
Possible Recommendations:
- Keep up a healthy diet and regular exercise
- Continue to monitor high cholesterol and treat appropriately
- Evaluate strategies to reduce stress
- Consider Ubiquinol to support optimal heart health and replenish CoQ10 levels1-8
Cholesterol-lowering statins can significantly lower the amount of CoQ10 (ubiquinone) in the blood4-7
- Statins can lower the amount of CoQ10 in the blood, even when a patient has taken a standard dose for as few as 3 months9
- Ubiquinol has been shown to replenish depleted levels of CoQ10 from statin medication use10,11
- Read more about how statins lower CoQ10
Mark: "I already take a multivitamin—do I need to add Ubiquinol?"
Ubiquinol is not in multivitamins
- Ubiquinol is delivered via softgels (it is fat-soluble, not water-soluble)
- Ubiquinol is more readily absorbed in the body and is more bioavailable than conventional CoQ1012-14
- Ubiquinol is the only form of CoQ10 that functions as an antioxidant15
References
- Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta. 1992;1126(3):247-254.
- Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci USA. 1991;88(5):1646-1650.
- Alleva R, Tomasetti M, Bompadre S, Littarru GP. Oxidation of LDL and their subfractions: kinetic aspects and CoQ10 content. Mol Aspects Med. 1997;Suppl 18:S105-S112.
- Schmelzer C, Niklowitz P, Okun JG, et al. Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. IUBMB Life. 2011;63(1):42-48.
- Dhingra R, Gona P, Wang TJ, Fox CS, D’Agostino, RB, Vasan RS. Serum gamma glutamyl transferase and risk of heart failure in the community. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1855–1860.
- Onur S, Niklowitz P, Jacobs G, et al. Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. BMC Res Notes. 2014;7:427.
- Onur S, Niklowitz P, Jacobs G, et al. Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, in healthy elderly subjects. BioFactors. 2015;41(1):35-43.
- Fischer A, Onur S, Niklowitz P, et al. Coenzyme Q10 redox state predicts the concentration of c-reactive protein in a large caucasian cohort. BioFactors. 2016;42(3):268-276.
- Passi S, Stancato A, Aleo E, et al. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. BioFactors. 2003;18(1-4):113-124.
- Zlatohlavek L, Vrablik M, Grauova B, et al. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33 suppl 2:98-101.
- Fedacko J, Pella D, Fedackova P, et al. Coenzyme Q10 and selenium in statin-associated myopathy treatment. Can J Physiol Pharmacol. 2013;91(2):165-170.
- Miles MV, Horn P, Miles L et al. Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res. 2002;22(8):919-929.
- Evans M, Baisley J, Barss S, Guthrie N. A randomized, double-blind trial on the bioavailability of two CoQ10 formulations. J Funct Foods. 2009;1:65-73.
- Langsjoen PH, Langsjoen AM. Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev. 2013;3(1):13-17.
- Ernster L, Forsmark-Andrée P. Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin Investig. 1993;71(suppl 8):S60-S65.
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