Ubiquinol improves arterial health to support blood circulation

Ubiquinol significantly improves endothelial function1

In an 8-week, randomized, double-blind, single-center trial, with the primary outcome of change in flow-mediated dilation (FMD) in healthy patients with mild-to-moderate dyslipidemia, Ubiquinol significantly improved dyslipidemia-related endothelial dysfunction (P=0.001).

endothelial function

*Response with Ubiquinol was dose-independent.
†No significant changes in plasma lipid profile between groups or versus baseline for either group (one-way ANOVA, P=0.905). Ubiquinol improved endothelium-dependent vasodilation independent of plasma cholesterol levels.

Cardiovascular health is associated with many factors, including diet, lifestyle and genetics. According to a 2019 expert consensus report, each 1% increase in FMD involves a significant 8% to 13% reduction in the risk of cardiovascular events.2

Significant improvements on 3 secondary endpoints

  • Ubiquinol increased plasma CoQ10 levels versus placebo (P<0.001), and reduced the percentage of oxidized CoQ10 (P<0.001)
  • Serum NOx increased significantly in subjects receiving Ubiquinol (P=0.016) versus placebo
    • Increase in NOx was dose-independent (no significant difference between the 100 mg and 200 mg Ubiquinol-treated groups) (P=0.049)
  • LDL oxidation lag time improved significantly in those receiving 200 mg/day Ubiquinol (P=0.017) versus placebo

The improvement in endothelial function with Ubiquinol was positively correlated with increased NOx concentration (P=0.012) and increased LDL lag time over the course of the study (P=0.031)

An 8-week, randomized, double-blind trial

study design

Patients were healthy with mild-to-moderate dyslipidemia

table

Ubiquinol significantly improved endothelial function in cardiac patients with reduced ejection fraction3

In a separate small, double-blind, placebo-controlled pilot study of 14 patients with HFrEF (heart failure with reduced ejection fraction), Ubiquinol 400 mg/day for 3 months provided significant improvement in peripheral endothelial function (EF)

  • Peripheral endothelial function was assessed using the reactive hyperemia index (RHI)
  • RHI significantly improved with Ubiquinol (P=0.026) but not with placebo (P=0.198)

Request Patient Samples

References

  1. Sabbatinelli J, Orlando P, Galeazzi R. Ubiquinol ameliorates endothelial dysfunction in subjects with mild-to-moderate dyslipidemia: a randomized clinical trial. Nutrients. 2020;12(4):1098. doi: 10.3390/nu12041098.

  2. Thijssen DHJ, Bruno RM, van Mil A, et al. Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans. Eur Heart J. 2019;40:2534-2547.

  3. Kawashima C, Matsuzawa Y, Konishi M, et al. Ubiquinol improves endothelial function in patients with heart failure with reduced ejection fraction: a single-center, randomized double-blind placebo-controlled crossover pilot study. Am J Cardiovasc Drugs. 2019. doi:10.3390/nu12041098.