Anna
*Not an actual patient
Age 45
Presentation
- Anna is in your office for an annual exam
- She is a money manager
- Married, 2 kids
- Nonsmoker who drinks 3x/week and runs a mile daily with her dog
- Has tried different diets in the past 2 years—vegetarian, paleo, and ketogenic—but abandoned them
History
- High blood pressure
Current Medications/Supplements
- NSAID in the morning for occasional joint or back pain
- Losartan for hypertension
- Multivitamin with calcium, omega-3 fish oil, CoQ10 daily
Anna asks, "What else can I do for my health as I get older?"
For patients over 40 who are taking CoQ10, consider recommending they switch to Ubiquinol
Possible Recommendations:
- Continue regular exercise
- Choose a healthy diet that can be maintained over time
- Consider Ubiquinol, the active form of CoQ10, which is more bioavailable than CoQ10
Ubiquinol plays a critical role in creating cellular energy for organs and muscles, including the brain and the heart1
- More than 90% of CoQ10 in the blood of a healthy young adult is in the active Ubiquinol form2-4
- However, after 40, a patient's ability to turn conventional (oxidized) CoQ10 into Ubiquinol diminishes and becomes less efficient5,6
- Only Ubiquinol, the active form of CoQ10, acts as an antioxidant, protecting cells from the oxidative stress caused by free radicals7,8
Anna: "Isn't Ubiquinol the same thing as the CoQ10 I already take?"
The body needs to convert oxidized CoQ10 into Ubiquinol before it can be used to create cellular energy9
- Ubiquinol is more readily absorbed in the body and more bioavailable than conventional CoQ1010-12
- Read more about the difference between CoQ10 and Ubiquinol
References
- Becker WM, Deamer DW. The World of the Cell, 2nd ed. Redwood City, CA: Benjamin Cummings Publishing Company, Inc; 1991:275-313.
- Yamamoto Y, Yamashita S. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal Biochem. 1997;250(1):66-73.
- Hosoe K, Kitano M, Kishida H, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007;47(1):19-28.
- Tomasetti M, Alleva R, Borghi B, Collins AR. In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB J. 2001;15(8):1425-1427.
- Wada H, Goto H, Hagiwara S-I, Yamamoto Y. Redox status of coenzyme Q10 is associated with chronological age. JAGS. 2007;55(7):1141-1142.
- Niklowitz P, Onur S, Fisher A, et al. Coenzyme Q10 serum concentration and redox status in European adults: influence of age, sex, and lipoprotein concentration. J Clin Biochem Nutr. 2016;58(3):240-245.
- Forsmark-Andrée P, Ernster L. Evidence for a protective effect of endogenous ubiquinol against oxidative damage to mitochondrial protein and DNA during lipid peroxidation. Mol Aspects Med. 1994;15(suppl 1):S73-S81.
- Ernster L, Forsmark-Andrée P. Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin Investig. 1993;71(suppl 8):S60-S65.
- Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta. 1992;1126(3):247-254.
- Langsjoen PH, Langsjoen AM. Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev. 2013;3(1):13-17.
- Miles MV, Horn P, Milesc L, et al. Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res. 2002:22(8):919-929.
- Evans M, Baisley J, Barss S, Guthrie N. A randomized, double-blind trial on the bioavailability of two CoQ10 formulations. J Funct Foods. 2009;1:65-73.
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