Published Research

Alleva R, Tomasetti M, Bompadre S, Littarru GP. Oxidation of LDL and their subfractions: kinetic aspects and CoQ10 content. Mol Aspects Med. 1997;18 Suppl:S105-12.

Becker WM, Deamer DW. The World of the Cell, 2nd ed. Redwood City, CA: Benjamin Cummings Publishing Company, Inc; 1991:275-313.

De Pinieux G, Chariot P, Ammi-Saïd M, et al. Lipid-lowering drugs and mitochondrial function: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br J Clin Pharmacol. 1996;42(3):333-337.

Dhingra R, Gona P, Wang T, et al. Serum g-glutamyl transferase and risk of heart failure in the community. Arterioscler Thromb Vasc Biol. 2010;30(9):1855-1860.

Dhingra R, Gona P, Wang TJ, Fox CS, D’Agostino, RB, Vasan RS. Serum gamma glutamyl transferase and risk of heart failure in the community. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1855–1860.

Ernster L, Forsmark-Andrée P. Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin Investig. 1993;71(8 Suppl):S60-5.

Evans M, Baisley J, Barss S, Guthrie N. A randomized, double-blind trial on the bioavailability of two CoQ10 formulations. J Funct Foods. 2009;1:65-73.

Fedacko J, Pella D, Fedackova P, Hänninen O, Tuomainen P, Jarcuska P, Lopuchovsky T, Jedlickova L, Merkovska L, Littarru GP. Coenzyme Q(10) and selenium in statin-associated myopathy treatment. Can J Physiol Pharmacol. 2013 Feb;91(2):165-70.

Fischer A, Onur S, Niklowitz P, et al. Coenzyme Q10 redox state predicts the concentration of c-reactive protein in a large caucasian cohort. BioFactors. 2016;42(3):268-276.

Forsmark-Andrée P, Ernster L. Evidence for a protective effect of endogenous ubiquinol against oxidative damage to mitochondrial protein and DNA during lipid peroxidation. Mol Aspects Med. 1994;15(suppl 1):S73-S81.

Frei B, Kim MC, Ames BN. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci U S A. 1990 Jun;87(12):4879-83.

Hosoe K, Kitano M, Kishida H, Kubo H, Fujii K, Kitahara M. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol. 2007 Feb;47(1):19-28.

Kalen A, Appelkvist E-L, Daliner G. Age-related changes in the lipid compositions of rat and human tissues. Lipids. 1989;24(7):579-584.

Kawashima C et al. Ubiquinol improves endothelial function in patients with heart failure with reduced ejection fraction: A single center, randomized double-blind placebo-controlled cross-over study. Circulation. 2016;134 Suppl 1 Abstract 14946.

Kubo H, Fujii K, Kawabe T, et al. Food content of ubiuqinol-10 and ubiquinone-10 in the Japanese diet. J Food Comp Anal. 2008;21(3):199-210.

Langsjoen PH, Langsjoen AM. Comparison study of plasma coenzyme Q10 levels in healthy subjects supplemented with ubiquinol versus ubiquinone. Clin Pharmacol Drug Dev. 2013;3(1):13-17.

Langsjoen PH, Langsjoen AM. Supplemental ubiquinol in patients with advanced congestive heart failure. BioFactors. 2008;32(1-4):119-128.

Langsjoen PH, Langsjoen AM. Supplemental ubiquinol in congestive heart failure—3 year experience. Presented at: 6th International CoQ10 Association Conference; May29, 2010; Brussels, Belgium.

Lobo V, Patil A, Phatak A, Chandra N. Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev. 2010;4(8):118-126.

Miles MV, Horn P, Miles L et al. Bioequivalence of coenzyme Q10 from over-the-counter supplements. Nutr Res. 2002;22(8):919-929.

Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta. 1992 Jun 26;1126(3):247-54.

Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med Suppl. 1997;18:S137-S144.

Niklowitz P, Onur S, Fisher A, et al. Coenzyme Q10 serum concentration and redox status in European adults: influence of age, sex, and lipoprotein concentration. J Clin Biochem Nutr. 2016;58(3):240-245.

Onur S, Niklowitz P, Jacobs G, et al. Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, in healthy elderly subjects. BioFactors. 2015;41(1):35-43.

Onur S, Niklowitz P, Jacobs G, et al. Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. BMC Res Notes. 2014;7:427.

Onur S, Niklowitz P, Jacobs G, Lieb W, Menke T, Döring F. Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, in healthy elderly subjects. Biofactors. 2015 Jan-Feb;41(1):35-43.

Onur S, Niklowitz P, Jacobs G, Nöthlings U, Lieb W, Menke T, Döring F. Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. BMC Res Notes. 2014 Jul 4;7:427.

Passi S, Stancato A, Aleo E, et al. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. BioFactors. 2003;18(1-4):113-124.

Schmelzer C, Niklowitz P, Okun JG, et al. Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. IUBMB Life. 2011;63(1):42-48.

Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1646-50.

Tang PH, Miles MV, DeGrauw A, et al. HPLC analysis of reduced and oxidized coenzyme Q10 in human plasma. Clin Chem. 2001;47(2):256-265.

Tomasetti M, Alleva R, Borghi B, Collins AR. In vivo supplementation with coenzyme Q10 enhances the recovery of human lymphocytes from oxidative DNA damage. FASEB J. 2001 Jun;15(8):1425-7.

Wada H, Goto H, Hagiwara S-I, Yamamoto Y. Redox status of coenzyme Q10 is associated with chronological age. JAGS. 2007;55(7):1141-1142.

Watts GF, Castelluccio C, Rice-Evans C, et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J Clin Pathol. 1993;46:1055-1057.

Yamamoto Y. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal Biochem. 1997 Jul 15;250(1):66-73.

Zlatohlavek L, Vrablik M, Grauova B, Motykova E, Ceska R. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett. 2012;33 Suppl 2:98-101.

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