Stephanie
*Not an actual patient
Age 59
Presentation
- Patient comes in for annual exam
- Stephanie is an elementary school principal
- Divorced, with 1 child in college
- Smokes on occasion (socially) and goes out for drinks once a week
- Sedentary, states she does not have time to exercise
History
- Family history of cardiovascular disease; her father died at age 67 from a myocardial infarction
- Diagnosed last year with type 2 diabetes
Current Treatment
- Started metformin at diabetes diagnosis
- Prefers natural remedies; for example, she uses comfrey cream for her occasional back pain
Stephanie asks, "What else can I do for my heart? Sometimes I worry I’m not doing enough"
For the patient with heart health concerns, consider Ubiquinol
Possible Recommendations:
- Continue to monitor diabetes and treat appropriately
- Try to quit smoking
- Introduce regular, light exercise
- Reevaluate diet and choose healthy foods
- Consider Ubiquinol to support optimal heart health1-3
Ubiquinol plays a role in heart health through multiple mechanisms
- Ubiquinol helps to protect against lipid peroxidation4-6
- Ubiquinol is more effective than lipid-soluble vitamin E in protecting against lipid peroxidation7,8
- Ubiquinol can improve markers associated with heart health, including reduction of GGT (gamma-glutamyltransferase), a marker of oxidative health9-12
- Ubiquinol acts as an antioxidant and provides cellular defense against oxidative damage7,13
- Read more about how Ubiquinol supports optimal heart health.
Stephanie: "Can't I just get Ubiquinol through what I eat?"
A typical daily serving of Ubiquinol is 100 milligrams
- Ubiquinol is found in some foods (cabbage, broccoli, oysters, liver, avocados, oranges), but only in very small amounts14
- For example, you would have to eat 60 avocados to get the same amount of Ubiquinol in one 100 mg Kaneka Ubiquinol capsule15
References
- Langsjoen PH, Langsjoen AM. Supplemental ubiquinol in patients with advanced congestive heart failure. BioFactors. 2008;32(1-4):119-128.
- Langsjoen PH, Langsjoen AM. Supplemental ubiquinol in congestive heart failure—3 year experience. Presented at: 6th International CoQ10 Association Conference; May 29, 2010; Brussels, Belgium.
- Schmelzer C, Niklowitz P, Okun JG, et al. Ubiquinol-induced gene expression signatures are translated into altered parameters of erythropoiesis and reduced low density lipoprotein cholesterol levels in humans. IUBMB Life. 2011;63(1):42-48.
- Mohr D, Bowry VW, Stocker R. Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta. 1992;1126(3):247-254.
- Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol. Proc Natl Acad Sci USA. 1991;88(5):1646-1650.
- Alleva R, Tomasetti M, Bompadre S, Littarru GP. Oxidation of LDL and their subfractions: kinetic aspects and CoQ10 content. Mol Aspects Med. 1997;Suppl 18:S105-S112.
- Ernster L, Forsmark-Andrée P. Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin Investig. 1993;71(suppl 8):S60-S65.
- Frei B, Kim MC, Ames BN. Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations. Proc Natl Acad Sci USA. 1990;87(12):4879-4883.
- Dhingra R, Gona P, Wang T, et al. Serum γ-glutamyl transferase and risk of heart failure in the community. Arterioscler Thromb Vasc Biol. 2010;30(9):1855-1860.
- Onur S, Niklowitz P, Jacobs G, et al. Ubiquinol reduces gamma glutamyltransferase as a marker of oxidative stress in humans. BMC Res Notes. 2014;7:427.
- Onur S, Niklowitz P, Jacobs G, et al. Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, in healthy elderly subjects. BioFactors. 2015;41(1):35-43.
- Fischer A, Onur S, Niklowitz P, et al. Coenzyme Q10 redox state predicts the concentration of c-reactive protein in a large caucasian cohort. BioFactors. 2016;42(3):268-276.
- Forsmark-Andrée P, Ernster L. Evidence for a protective effect of endogenous ubiquinol against oxidative damage to mitochondrial protein and DNA during lipid peroxidation. Mol Aspects Med. 1994;15(suppl 1):S73-S81.
- Kubo H, Fujii K, Kawabe T, et al. Food content of ubiuqinol-10 and ubiquinone-10 in the Japanese diet. J Food Comp Anal. 2008;21(3):199-210.
- Data on file. Kaneka North America LLC.
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