If you’re a patient with an age-related disease, or if you’re just looking to stay healthy as you grow older, ubiquinol helps support and promote both healthy energy levels and optimal heart health. Clinical studies and academic research indicate that ubiquinol may have more benefits than traditional Coenzyme Q10 supplements because ubiquinol is more bioavailable, meaning it's more easily aborbed and used by the body than conventional CoQ10. As the fully reduced, active form of CoQ10, ubiquinol is an essential component required for the mitochondrial synthesis of energy, and ubiquinol is required for 95 percent of the body's cellular energy production. In fact, ubiquinol is found in every cell of your body and has been called "the nutrient for the new century."
History of CoQ10 - The Early Years
It was Dr. Frederick Crane from the University of Wisconsin that isolated Coenzyme Q10 for the first time from an actual cow heart. But it wasn’t until 1958 that Dr. Karl Folkers identified the precise chemical structure. He was also responsible for developing the first process that revolutionized CoQ10 synthesis. Even after these discoveries, it wasn’t until 1968 that the first clinical research was accepted by the medical community for publication in medical journals. In the early 1970s, the Japanese medical community approved the use of CoQ10 as a dietary supplement for their advanced cardiac patients. Today, after 40 years and numerous clinical studies, ubiquinol has gained recognition for its ability to promote heart health, support energy production and help prevent damage caused by free radicals and oxidative stress. Part of the reason ubiquinol is so effective is because it has been shown to be better absorbed than conventional Coenzyme Q10 and therefore more effective at replenishing the normal CoQ10 plasma concentration.
What Makes Ubiquinol a Natural Nutrient?
Ubiquinol is the only fat-soluble antioxidant that the body naturally produces. As we age, our bodies produce less CoQ10 and become less able to convert it into ubiquinol, which is the form of CoQ10 that our bodies use in 95 percent of cellular energy production. Unlike ubiquinone – the form of CoQ10 found in conventional supplements – ubiquinol does not need to be converted by our bodies to be fully utilized. Ubiquinol is found in the tissues of every organ, but it’s most prevalent within the heart. But preliminary studies have shown that the CoQ10 balance (Ubiquinol versus total CoQ10) is affected by both aging and chronic disease and that ubiquinol levels are significantly diminished by aging and conditions marked by high oxidative stress. A 2010 study from Germany’s Christian-Albrechts-University of Kiel had clinical researchers testing the CoQ10-versus-ubiquinol hypothesis to determine which nutrient was more efficient at increasing total CoQ10 levels found in the body. By profiling genome expressions from the heart, liver, brain and kidneys of mice given either ubiquinol or CoQ10 (ubiquinone), scientists discovered that ubiquinol was far more successful than CoQ10 (ubiquinone) at increasing the total CoQ10 levels. With higher levels of available CoQ10 in their systems, subjects showed improved organ function, higher metabolism and lowered inflammation.
Cardiologist Peter Langsjoen’s Clinical Study of the Century
Perhaps the most recognizable research on ubiquinol comes from Cardiologist Dr. Peter Langsjoen. In the first clinical trial of its kind, Dr. Langsjoen evaluated the effects of ubiquinol on patients suffering from advanced congestive heart failure. At the beginning of the clinical trial, each patient’s evaluation noted that his or her life expectancy was no longer than six months. These critically ill patients were supplemented with ubiquinol for three months, and by the end of the trial, each one had experienced a 24 percent to 50 percent increase in ejection fraction, which is the heart’s ability to pump blood. Each patient demonstrated improved mobility and function. All patients showed striking improvements in classification when evaluated against the NYHA (New York Heart Association). Overall, the group moved from a mean of Class IV (bedridden) to a mean of Class II (slight limitation during activity). More importantly, their plasma levels of CoQ10 had more than tripled. Every patient survived beyond the researchers’ expectations.
Such results from these clinical studies are the reason ubiquinol has been called "the nutrient of the new century." Studies have found that ubiquinol is more easily and efficiently absorbed by the body than CoQ10 and can replenish normal CoQ10 levels in the blood. In several studies, ubiquinol increased by an average of 4 times in healthy people taking 150-300 mg per day. With higher levels of this electron-rich form of CoQ10 in the body, ubiquinol can help prevent damage from free radical and protects cells from oxidative stress. Ubiquinol is naturally produced within the body, but taking ubiquinol supplements can help restore the levels of ubiquinol in your system that decline with age as well as promote energy production and support optimal heart health.
This article is for general educational purposes only and is not intended to be used as or substituted for medical advice. Always seek the advice of your physician or qualified health care provider with any questions about your health or a medical condition. Never disregard or delay seeking medical advice because of something you have read on the internet.