Why Do People Take Ubiquinol With Statins?

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Ubiquinol and Statins

Statins, or cholesterol-lowering medications, lower the body’s production of CoQ10, which can lead to a deficiency in Ubiquinol levels 1,2,3,4 . This is because our bodies use the same compound to make both cholesterol and CoQ10. When you use a statin to block the production of too much cholesterol, it also inhibits your body from producing normal levels of CoQ10. Luckily, by taking a Ubiquinol CoQ10 dietary supplement, you can replenish depleted levels of this important nutrient. To learn more about Ubiquinol and statins, visit ubiquinol.org, and talk to your doctor about starting a Ubiquinol supplement.

The Connection Between CoQ10 And Cholesterol

Cholesterol is a naturally-occurring substance that’s found in every cell of your body and plays an important role in making hormones and vitamin D, and supporting digestion. However, too much cholesterol can cause health problems. If you have high cholesterol, your doctor may prescribe you a statin. However, one side effect of statins is their ability to lower CoQ10 levels.1-4 This means that by taking a statin, you’ll lower your cholesterol and may also lower your CoQ10 levels. Lower CoQ10 levels lead to less Ubiquinol in your body. Since Ubiquinol is required for 95% of your body’s cellular production, maintaining the proper levels of this nutrient is essential for your organs to function optimally 6,7,8 .

Ubiquinol and Statin Research

Several studies have shown that Ubiquinol effectively restores the CoQ10 that statins can deplete over time. Research also shows that when compared to conventional CoQ10, Ubiquinol is better able to replenish CoQ10 levels in statin users.

1Passi S, Stancato A, Aleo E, Dmitrieva A, Littarru GP. Statins lower plasma and lymphocyte ubiquinol/ubiquinone without affecting other antioxidants and PUFA. Biofactors. 2003;18(1-4):113-24.

2 De Pinieux G, Chariot P, Ammi-Said M et al., Lipid-lowering drugs and mitochondrial functions: effects of HMG-CoA reductase inhibitors on serum ubiquinone and blood lactate/pyruvate ratio. Br. J. Clin. Pharmacol. 1996;42(3):333–337.

3Mortensen SA, Leth A, Agner E, Rohde M. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med Suppl 1997;18: S137–144.

4Watts GF, Castellucci C, Rice-Evans C et al., Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J. Clin Pathol. 1993;46(11):1055–1057.


6Tang PH, Miles MV, DeGrauw A, Hershey A, Pesce A. HPLC analysis of reduced and oxidized coenzyme Q(10) in human plasma. Clin Chem. 2001 Feb;47(2):256-65.

7Yamashita S, Yamamoto Y. Simultaneous detection of ubiquinol and ubiquinone in human plasma as a marker of oxidative stress. Anal Biochem. 1997 Jul 15;250(1):66-73.

8Aberg F, Appelkvist EL, Dallner G, Ernster L. Distribution and redox state of ubiquinones in rat and human tissues. Arch Biochem Biophys. 1992 Jun;295(2):230-4.

Written by:

Risa Schulman


Risa Schulman, Ph.D. took her lifelong love of science, people and the fulfillment of potential to create a multifaceted career in R&D, business, health and wellness, and empowering individuals. 

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